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	Provedor de dados Biol. Res. (2) Autor BULL,RICARDO (2) DONOSO,PAULINA (2) HIDALGO,CECILIA (2) BEHRENS,M. ISABEL (1) MARENGO,JUAN J (1) PÉREZ,CLAUDIO F (1) Mais... Palavra-chave Redox state (2) Ryanodine receptors (2) Calcium dependence (1) Calcium release (1) Neurons (1) S-glutathionylation (1) S-nitrosylation (1) Sarcoplasmic reticulum (1) Sarcoplasmic/endoplasmic reticulum (1) Skeletal and cardiac muscle (1) Mais... Tipo do documento Journal article (2) Ano 2004 (1) 2000 (1) País Chile (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Redox regulation of RyR-mediated Ca2+ release in muscle and neurons Biol. Res. HIDALGO,CECILIA; BULL,RICARDO; BEHRENS,M. ISABEL; DONOSO,PAULINA. Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well. Tipo: Journal article Palavras-chave: Redox state; Ryanodine receptors; Sarcoplasmic/endoplasmic reticulum; Calcium release; S-nitrosylation; S-glutathionylation. Ano: 2004 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400007 SH Oxidation Stimulates Calcium Release Channels (Ryanodine Receptors) From Excitable Cells Biol. Res. HIDALGO,CECILIA; BULL,RICARDO; MARENGO,JUAN J; PÉREZ,CLAUDIO F; DONOSO,PAULINA. The effects of redox reagents on the activity of the intracellular calcium release channels (ryanodine receptors) of skeletal and cardiac muscle, or brain cortex neurons, was examined. In lipid bilayer experiments, oxidizing agents (2,2'-dithiodipyridine or thimerosal) modified the calcium dependence of all single channels studied. After controlled oxidation channels became active at sub µM calcium concentrations and were not inhibited by increasing the calcium concentration to 0.5 mM. Subsequent reduction reversed these effects. Channels purified from amphibian skeletal muscle exhibited the same behavior, indicating that the SH groups responsible for modifying the calcium dependence belong to the channel protein. Parallel experiments that... Tipo: Journal article Palavras-chave: Calcium dependence; Neurons; Redox state; Ryanodine receptors; Sarcoplasmic reticulum; Skeletal and cardiac muscle. Ano: 2000 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200011 Registros recuperados: 2 Primeira ... 1 ... Última

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